[Development of a measuring tool for performance anxiety in obstetrics]. / Développement d'un outil d'évaluation de l'anxiété de performance en obstétrique.

OBJECTIVE: Developing a measuring tool for physician's performance anxiety during obstetrical procedures, as a self-administered questionnaire. METHODS: We used the Delphi method. First, we did a literature review to identify the items to submit for the first round. A panel of experts was asked to rate the relevance of items from one to six. For the first round of Delphi, items were retained if more than 70% of respondents assigned a five or six rating. Items were excluded if more than 70% of respondents assigned a one or two rating. All the other items, plus those suggested by the panel, were submitted to a second round of Delphi. The same item selection conditions were applied to the second round. RESULTS: The overall response rate to the Delphi was 79% (19 respondents). At the end of the first round, 14 items were consensually relevant, no item was consensually irrelevant. For the second round, the 18 items that did not find consensus and seven new items suggested by the experts in the first round were submitted. At the end of the second round, nine items were retained by consensus as relevant. CONCLUSION: This study defined by consensus 23 items for a self-questionnaire to measure specific performance anxiety in obstetrics divided into five dimensions: perceived stress, assessment of the risk of complications, medico-legal risk, impact of the healthcare team and peers, self-confidence and decision-making confidence. We intend to validate this tool in real population.

ChatGPT for phenotypes extraction: one model to rule them all?

Information Extraction (IE) is a core task in Natural Language Processing (NLP) where the objective is to identify factual knowledge in textual documents (often unstructured), and feed downstream use cases with the resulting output. In genomic medicine for instance, being able to extract the most precise list of phenotypes associated to a patient allows to improve genetic disease diagnostic, which represents a vital step in the modern deep phenotyping approach. As most of the phenotypic information lies in clinical reports, the challenge is to build an IE pipeline to automatically recognize phenotype concepts from free-text notes. A new machine learning paradigm around large language models (LLM) has given rise of an increasing number of academic works on this topic lately, where sophisticated combinations of different technics have been employed to improve the phenotypes extraction accuracy. Even more recently released, the ChatGPT1 application nevertheless raises the question of the relevance of these approches compared to this new generic one based on an instruction-oriented LLM. In this paper, we propose a rigorous evaluation of ChatGPT and the current state-of-the-art solutions on this specific task, and discuss the possible impacts and the technical evolutions to consider in the medical domain.Clinical relevance- Deep phenotyping on electronic health records has proven its ability to improve genetic diagnosis by clinical exomes [10]. Thus, comparing state-of-the-art solutions in order to derive insights and improving research paths is essential.

Feasibility and efficiency of delayed ovarian stimulation and metaphase II oocyte banking for fertility preservation and childbearing desire after fertility-impairing treatment.

The aim of our study was to evaluate the feasibility and efficiency of delayed ovarian stimulation and metaphase II oocyte banking for fertility preservation after fertility-impairing treatment regardless of the initial disease. We conducted a cohort study based on population of women < 40 years of age with diminished ovarian reserve caused by fertility-impairing treatment (n = 129). Three groups of women were compared according to the type of initial disease: hematological malignancies, solid tumors, and benign diseases. The primary endpoint was the number of metaphase II oocytes collected per woman. We studied the cumulative live-birth rate per cycle with fertilized metaphase II oocyte, for women who wanted to conceive. We studied 245 delayed controlled ovarian stimulation cycles in 129 women: 201 for fertility preservation and 44 for in vitro fertilization and fresh embryo transfers. The number of metaphase II oocytes collected per woman after banking was similar in the three groups, with a mean of 10.7 ± 4.6, 12.3 ± 9.1, and 10.1 ± 7.6 metaphase II oocytes (p = 0.46), respectively. In the subgroup of women who wanted to conceive, the cumulative live birth rate per woman was 38%, with 8 live births for these 21 women. After fertility-impairing treatment, practitioners should discuss a fertility preservation procedure for banking metaphase II oocytes.

Acute Bartholin's gland abscess treatment by simple needle aspiration: A prospective study.

OBJECTIVE: This study aim was to examine the success rate of simple needle aspiration for acute Bartholin's gland abscess and compare it to incision and drainage treatment. STUDY DESIGN: This was a non-randomised prospective study conducted at the academic Hospital of La Conception, Marseille, France. We included 202 women who presented with acute Bartholin's gland abscess between June 2013 and October 2017. The study cohort was subdivided into two treatment groups, simple needle aspiration (134 women) or incision and drainage (42 women), according to the women's preference. Success was considered as the absence of surgical treatment within one year of the initial treatment. RESULTS: The success rate was 68/134 (51% (95% CI: 42-59%)) in the simple needle aspiration group and 25/42 (60%) in the incision drainage group (RR: 0.85, 95% CI: 0.63-1.15, P = 0.3). Among 122/134 (91%) women who completed the satisfaction survey, 99/122 (81%) were satisfied with the simple needle aspiration. CONCLUSIONS: Simple needle aspiration can be offered as first-line treatment for acute Bartholin's gland abscess. Simple needle aspiration can be performed as an outpatient procedure without general anesthesia avoiding surgical treatment in half of the cases one-year post- simple needle aspiration.

Uncertain fetal head engagement: a prospective randomized controlled trial comparing digital exam with angle of progression.

BACKGROUND: Uncertain fetal head engagement represents 4% of obstetrical situations associated with an increased risk of postpartum hemorrhage, notably in cases of cesarean delivery and increased neonatal impairment owing to failed vaginal instrumental delivery. In this obstetrical condition, cesarean delivery is recommended, but vaginal delivery is possible in two-thirds of the cases. During the second stage of labor, the descent of the fetal head can be assessed by sonography, particularly by measuring the angle of progression. OBJECTIVE: To evaluate, after a prolonged second stage of labor, the impact of measuring the angle of progression in addition to a digital examination on cesarean delivery rates when fetal head engagement remains uncertain. STUDY DESIGN: This open multicenter randomized pragmatic trial included women at term with a singleton cephalic fetus in a clinical occiput anterior position after a prolonged 2-hour second stage of labor with uncertain fetal head engagement. After inclusion in the study, an independent investigator performed ultrasound systematically to confirm the occiput anterior position and measured the angle of progression at the climax of Valsalva pushing. This operator did not participate in labor management. In the study group but not in the control group, the angle of progression was communicated to the obstetrician in charge of labor management. Obstetricians were encouraged to attempt vaginal birth if the angle of progression was >120°. The primary outcome was the cesarean delivery rate. Secondary outcomes were operative delivery rate (cesarean delivery and operative vaginal delivery), maternal complications (third and fourth-degree perineal tears, failed vaginal instrumental delivery, postpartum hemorrhage, hysterectomy), and neonatal outcomes (Apgar score <5 at 10 minutes, umbilical arterial pH <7.10, neonatal wounds, neonatal intensive care unit admission). RESULTS: A total of 45 women were included in the study. Occiput anterior position was confirmed in 33 women: 16 in the study group and 17 in the control group. Women's characteristics at baseline were similar between the groups. The median (range) angles of progression were similar: 138.4° (15) and 140.3° (16.9) in the study and control group, respectively. Cesarean delivery rates were 12.5% in the study group and 41.1% in the control group (P=.06). Secondary outcomes were similar between the 2 groups. No failed vaginal instrumental delivery was reported. CONCLUSION: Measurement of the angle of progression in addition to digital examination when fetal head engagement remained uncertain showed promising results in decreasing cesarean delivery rates. A larger multicenter randomized controlled trial is needed to confirm these results.

Prophylactic manual rotation of occiput posterior and transverse positions to decrease operative delivery: the PROPOP randomized clinical trial.

BACKGROUND: Persistent occiput posterior and occiput transverse positions are the most common malpositions of the fetal head during labor and are associated with prolonged second stage of labor, cesarean deliveries, instrumental deliveries, severe perineal tears, postpartum hemorrhage, and chorioamnionitis. Manual rotation is one of several strategies described to deal with these malpositions. OBJECTIVE: This study aimed to determine if the trial of prophylactic manual rotation at the early second stage of labor is associated with a decrease in operative deliveries (instrumental and/or cesarean deliveries). STUDY DESIGN: We conducted a multicenter, open-label, randomized controlled trial in 4 French hospitals. Women with singleton term pregnancy and occiput posterior or occiput transverse position confirmed by ultrasound at the early second stage of labor and with epidural analgesia were eligible. Women were randomly assigned (1:1) to either undergo a trial of prophylactic manual rotation of occiput posterior or occiput transverse position (intervention group) or no trial of prophylactic manual rotation (standard group). The primary outcome was operative delivery (instrumental and/or cesarean deliveries). The secondary outcomes were length of the second stage of labor, maternal complications (postpartum hemorrhage, operative complications during cesarean delivery, episiotomy and perineal tears), and neonatal complications (Apgar score of <5 at 10 minutes, arterial umbilical pH of <7.10, neonatal injuries, neonatal intensive care unit admission). The main analysis was focused on intention-to-treat analysis. RESULTS: From December 2015 to December 2019, a total of 257 women (mean age, 30.4 years; mean gestational age, 40.1 weeks) were randomized: 126 were assigned to the intervention group and 131 were assigned to the standard group. Operative delivery was significantly less frequent in the intervention group compared with the standard group (29.4% [37 of 126] vs 41.2% [54 of 131]; P=.047; differential [intervention-standard] [95% confidence interval] = -11.8 [-15.7 to -7.9]; unadjusted odds ratio [95% confidence interval] = 0.593 [0.353-0.995]). Women in the intervention group were more likely to have a significantly shorter second stage of labor. CONCLUSION: Trial of prophylactic manual rotation of occiput posterior or occiput transverse positions during the early second stage of labor was statistically associated with a reduced risk of operative delivery. This maneuver could be a safe strategy to prevention operative delivery.

Evaluation of PIG-A-mutated granulocytes and ex-vivo binucleated micronucleated lymphocytes frequencies after breast cancer radiotherapy in humans.

Although the PIG-A gene mutation frequency (MF) is considered a good proxy to evaluate the somatic MF in animals, evidence remains scarce in humans. In this study, a granulocyte PIG-A-mutant assay was evaluated in patients undergoing radiation therapy (RT) for breast cancer. Breast cancer patients undergoing adjuvant RT were prospectively enrolled. RT involved the whole breast, with (WBNRT) or without (WBRT) nodal area irradiation. Blood samples were obtained from participants before (T0) RT, and T1, T2, and T3 samples were collected 3 weeks after the initiation of RT, at the end of RT, and at least 10 weeks after RT discontinuation, respectively. The MF was assessed using a flow cytometry protocol identifying PIG-A-mutant granulocytes. Cytokinesis-blocked micronucleated lymphocyte (CBML) frequencies were also evaluated. Thirty patients were included, and five of them had received chemotherapy prior to RT. The mean (±SD) PIG-A MFs were 7.7 (±12.1) per million at T0, 5.2 (±8.6) at T1, 6.4 (±8.0) at T2 and 3.8 (±36.0) at T3. No statistically significant increases were observed between the PIG-A MF at T0 and the MFs at other times. RT significantly increased the CBML frequencies: 7.9 ‰ (±3.1‰) versus 33.6‰ (±17.2‰) (p < .0001). By multivariate analysis, the CBML frequency was correlated with age at RT initiation (p = .043) and irradiation volume at RT discontinuation (p = .0001) but not with chemotherapy. RT for breast cancer therapy failed to induce an increase in the PIG-A MF. The PIG-A assay in humans needs further evaluation, in various genotoxic exposures and including various circulating human cells.

Prenatal cannabinoid exposure alters the ovarian reserve in adult offspring of rats.

In animals, research in the past two decades has demonstrated the strong involvement of the endocannabinoid system (ECS) in numerous steps of the reproductive process, including ovarian physiology. Reproductive lifespan is closely related to the number of nongrowing ovarian follicles, called ovarian reserve (OR), which is definitively established during foetal life. Thus, OR damage may lead to poor reproductive outcomes and a shortened reproductive lifespan. We investigated whether prenatal ECS modulation had an effect on the OR at different ages in the rat offspring. Four groups of gestating female rats (F0) were exposed to the CB1-/CB2-receptor agonist WIN55212 (0.5 mg/kg), the CB1R inverse agonist SR141716 (3 mg/kg) or Δ9THC (5 mg/kg) and were compared to negative control groups. OR was histologically assessed at different postnatal timepoints (F1 individuals): postnatal day (PND) 6, PND40 and PND90. At PND6, prenatal exposure had no effect on OR. In the young adult group (PND90) exposed during gestation to WIN55212, we observed a CB1R-mediated delayed OR decrease, which was reversed by prenatal CB1R blockade by SR141716. Conversely, after prenatal SR141716 exposure, we observed higher OR counts at PND90. RT-PCR experiments also showed that prenatal ECS modulation perturbed the mRNA levels of ECS enzymes and OR regulation genes. Our findings support the role of the ECS in OR regulation during the foetal life of rats and highlight the need for further studies to elucidate its precise role in OR physiology.

[The PIG-A gene as a new biomarker of mutagenesis: proof of concept and technical specifications]. / Le gène PIG-A, nouveau marqueur de mutagenèse - Preuves de concept et exposé de la technique.

Gene mutations are not directly detected by current genotoxicity assays and most of them need a cell culture step. The whole blood PIG-A assay consists in the detection of the mutation frequency within the PIG-A sentinel gene by identification of glycosyl-phosphatidyl-inositol (GPI-) deficient cells. PIG-A mutated/GPI-deficient cells can be detected by flow cytometry as they no longer express surface fluorescence for GPI-linked markers. The last researches have focused on cell enrichment techniques leading to increased throughput and sensitivity. The results of this new and promising biomarker of mutagenesis, performed in humans or rodents, are now available within 2 hours after blood collection.

[Some Drops of Logic in the Fog of Depression]. / Algunas gotas de lógica en la niebla de las depresiones.

From two semi-popularised, but scientifically correct, texts, that provide a typical look of academic awareness of depressive phenomena, an attempt will be made to show what spontaneous medical naturalism involves, including the moral aspect of mental symptoms. The concept of moral from its common use that circles around the social and relational rules that make up the fabric of civilisation. This medical naturalism disqualifies, as an epiphenomenon, this fact: the intentional dimension of psychic facts, but also cases where the intention contained in a state of mind counts as intended, i.e. precisely the case where this state has a moral value. This is how depression is presented, as a moral pain. On the one hand, it is shown how a vision rejects and disavows intentionality in depressive states, rooting depression in a neurobiological state, and on the other, another one that tries to recover this intentionality through evolutionary postulates, but without actually achieving it. It is the ignorance of the moral grammar of depressive expressions and emotions, and of acts, as symbolic facts, that lead to naturalist illusions.

Algunas gotas de lógica en la niebla de las depresiones / Some Drops of Logic in the Fog of Depression

A partir de dos textos de semivulgarización, pero científicamente correctos, que rinden una mirada típica de la percepción académica de los fenómenos depresivos, nos esforzaremos en mostrar lo que implica el naturalismo médico espontáneo, que afecta al aspecto moral de los síntomas mentales, tomando el concepto de moral desde su uso común, alrededor de las reglas sociales y relacionales que componen el entramado de la civilización. Esta naturalización médica descalifica como epifenómeno este hecho: la dimensión intencional de los hechos psíquicos y también los casos en que la intención contenida en un estado mental cuenta como intención, es decir, justamente el caso en que este estado tiene valor moral; así es como se presenta la depresión, como un dolor moral. Por un lado, se muestra cómo una visión desconoce y rechaza esta intencionalidad en los estados depresivos, lo que arraiga la depresión en un estado neurobiológico, y por otro, otra que trata de recuperar esta intencionalidad a través de postulados evolucionistas, pero sin llegar a conseguirlo realmente. Es el desconocimiento de la gramática moral de las expresiones y de las emociones depresivas y de los actos como hechos simbólicos, que hacen desembocar en ilusiones naturalistas.

From two semipopularised, but scientifically correct, texts, that provide a typical look of academic awareness of depressive phenomena, an attempt will be made to show what spontaneous medical naturalism involves, including the moral aspect of mental symptoms. The concept of moral from its common use that circles around the social and relationalrules that make up the fabric of civilisation. This medical naturalism disqualifies, as an epiphenomenon, this fact: the intentional dimension of psychic facts, but also cases where the intention contained in a state of mind counts as intended, i.e. precisely the case where this state has a moral value. This is how depression is presented, as a moral pain. On the one hand, it is shown how a vision rejects and disavows intentionality in depressive states, rooting depression in a neurobiological state, and on the other, another one that tries to recover this intentionality through evolutionary postulates, but without actually achieving it. It is the ignorance of the moral grammar of depressive expressions and emotions, and of acts, as symbolic facts, that lead to naturalist illusions.

[Pathology seen in French "Hikikomori"].

Young people who meet the definition of "Hikikomori" have come to be seen in France since around 2008. However, simply "fitting the definition" does not necessarily mean that they are the same as "Hikikomori" in Japan. Rather, it is important to ask what kind of young people "fit the definition of Hikikomori in France" and what kind of pathology they have. With these questions, our Japanese-French joint research team comprising specialists in various fields conducted a survey of "Hikikomori" in French youth, with support from a Grant-in-Aid for Scientific Research B (overseas research), and started a comparative joint study on "Hikikomori" in Japan and "Hikikomori" in France. In that study it was found that whereas one aspect of "Hikikomori" in Japan is described by the word déraillement (coming off the "rails"), "Hikikomori" in France is a state closer to dropping out and is accompanied by a type of "sense of insufficiency". This "sense of insufficiency" is above all related to something in the society and culture of France, and an investigation of how it is linked to "Hikikomori" is an issue for the future.